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Evidence is increasing that all addiction without exception is related to difficulties with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in getting food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it one should err on the side of caution and allow FDA do its job and demand some research be done so that the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on their own medications.

Researchers found out that participants taking this drug for a year, dropped a few pounds within one month and have kept the extra weight off during the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, which can make them more potent and safer.

Combo-pilling will be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that by right now there aren't long term prescription slimming capsules that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug could also raise blood pressure level and heartbeat, and mustn't be used in individuals with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not used in patients with uncontrolled high blood pressure level, in addition to by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation.


A pyromaniac, with both psychiatric and medical therapy, can nevertheless be treated. It is best carried out with behavioral therapy. Psychotherapy treatment alongside behavior modification is the most frequently used treatment. Based on the study of Jon Grant, a mix treatment of drugs and behavioral therapy was found to be successful in treating pyromania. The utilization of serotonin reuptake inhibitors can be beneficial in managing the impulsive behavior from the patient such as other impulse control disorder. Also of great help for the patient are medications such as Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), and also other antidepressants.
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